Buy Phentermine Online

How does Phentermine work?

Phentermine works by stimulating the hypothalamus gland and affecting certain neurotransmitters to decrease appetite. The hypothalamus is the region of the brain that controls the autonomic nervous system, regulating sleep cycles, body temperature, appetite, etc.
Proper Use of Phentermine

Phentermine should be taken on an empty stomach, once daily, prior to breakfast. If in tablet form, the tablet may be broken or cut in half. Do NOT break, crush, or chew tablets.

As Phentermine may disrupt normal sleep patterns, avoid taking a dose late in the day. If taking more than one dose a day, take the last dose approx. 4-6 hours prior to going to bed.

The following information is specific only to the average doses of Phentermine. The recommended dose of Phentermine may be different for different patients. If your dose is different, do NOT change it unless your doctor tells you to do so.

Adults under Age 60

Oral dosage form (Capsules) - 15 to 37.5 mg once/day before breakfast or 1-2 hours after breakfast.

Oral dosage form (Tablets) - 15 to 37.5 mg once/day before breakfast or 1-2 hours after breakfast. Instead of taking it once a day, your doctor may tell you to take 15 to 37.5 mg in divided doses one-half hour before meals.

Oral resin dosage form (Capsules) - 15 to 30 mg once/day before breakfast.

Adults Age 60 and Over

A reduced dosage may be necessary. Consult your physician.

Infants and Children

Phentermine is NOT recommended for children under age 16.

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Mechanism of action

Phentermine, like many other prescription drugs, works with neurotransmitters in the brain. It is a centrally-acting stimulant and is a constitutional isomer (not to be confused with stereoisomer) of methamphetamine. It stimulates neuron bundles to release a particular group of neurotransmitters known as catecholamines; these include dopamine, epinephrine (also known as adrenalin), and norepinephrine (noradrenaline). The anorectic activity seen with these compounds is thus likely due to their effect on the central nervous system, which is consistent with current knowledge about the central nervous system and feeding behavior. This is the same mechanism of action as other stimulant appetite suppressants such as diethylpropion and phendimetrazine. The neurotransmitters signal a fight-or-flight response in the body which, in turn, puts a halt to the hunger signal. As a result, it causes a loss in appetite because the brain does not receive the hunger message.

Dosing and administration

Generally, it is recommended by the Food and Drug Administration (FDA) that phentermine should be used short-term (usually interpreted as ‘up to 12 weeks’), while following nonpharmacological approaches to weight loss such as healthy dieting and exercise. However, recommendations limiting its use for short-term treatment may be controversial. One reason given behind limiting its use to 12 weeks is drug tolerance, whereby phentermine loses its appetite-suppressing effects after the body adjusts to the drug. On the contrary, it has been shown that phentermine did not lose effectiveness in a 36-week trial.[2] Due to the risk of insomnia, it is generally recommended that the drug be taken either before breakfast or 1-2 hours after breakfast.

Contraindications and warnings

* Patients with the following should not use Phentermine:
o An allergy to any ingredient in Phentermine or other sympathomimetics (eg, pseudoephedrine)
o Are also taking dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) in the last 14 days
o Have severe high blood pressure, an overactive thyroid, glaucoma, heart or blood vessel disease, or severe narrowing of the blood vessels
o Are in an agitated state, or have a history of substance abuse
* Some medical conditions may interact with Phentermine, patients with the following should consult with their doctor before using phentermine:
o Are pregnant, planning to become pregnant, or are breast-feeding
o Are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
o Have allergies to medicines, foods, or other substances
o Have a brain or spinal cord disorder, hardening of the arteries, high blood pressure, diabetes, or high cholesterol or lipid levels
* Some medicines may interact with Phentermine, such as the following:
o Dexfenfluramine, fenfluramine, furazolidone, or MAOIs (eg, phenelzine) because the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increased
o Serotonin specific reuptake inhibitors (eg, fluoxetine) because the risk of their side effects may be increased by Phentermine
o Guanadrel or guanethidine because their effectiveness may be decreased by Phentermine

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